Immunodivergence in Metastatic Colorectal Cancer
de Andrea CE (1), Schalper KA (2), Sanmamed MF (3), Melero I (4)
Van den Eynde et al. publish in this issue of Cancer Cell that metastatic colorectal cancer shows marked heterogeneity in T cell infiltration among different lesions and patients. Measurements of T cell infiltration in metastases by immunoscore offer some prognostic information and support immune editing by coevolving adaptive immune responses.