Scientific publications

Immunodivergence in Metastatic Colorectal Cancer

Dec 10, 2018 | Magazine: Cancer Cell

de Andrea CE (1), Schalper KA (2), Sanmamed MF (3), Melero I (4)

(1) Clinica Universidad de Navarra, Pamplona, Spain; CIBERONC, Madrid, Spain.
(2) Department of Pathology, Yale University School of Medicine and Yale Cancer Center, New Haven, CT, USA.
(3) Clinica Universidad de Navarra, Pamplona, Spain; CIBERONC, Madrid, Spain; Center for applied Medical Research (CIMA), Pamplona, Spain.
(4) Clinica Universidad de Navarra, Pamplona, Spain; CIBERONC, Madrid, Spain; Center for applied Medical Research (CIMA), Pamplona, Spain; IDISNA, Pamplona, Spain. Electronic address: imelero@unav.es.


Abstract

Van den Eynde et al. publish in this issue of Cancer Cell that metastatic colorectal cancer shows marked heterogeneity in T cell infiltration among different lesions and patients. Measurements of T cell infiltration in metastases by immunoscore offer some prognostic information and support immune editing by coevolving adaptive immune responses.

CITATION  Cancer Cell. 2018 Dec 10;34(6):876-878. doi: 10.1016/j.ccell.2018.11.012