Hemostatic Biomarkers and Volumetry Help to Identify High-Risk Abdominal Aortic Aneurysms
Sebastian Fernandez-Alonso 1 2 , Esther Martinez-Aguilar 1 2 , Susana Ravassa 2 3 4 , Josune Orbe 2 4 5 , Jose A Paramo 2 4 5 6 , Leopoldo Fernandez-Alonso 1 2 , Carmen Roncal 2 4 5
Predicting the progression of small aneurysms is a main challenge in abdominal aortic aneurysm (AAA) management. The combination of circulating biomarkers and image techniques might provide an alternative for risk stratification.
We evaluated the association of plasma TAT complexes (TAT) and D-dimer with AAA severity in 3 groups of patients: group 1, without AAA (n = 52), group 2, AAA 40-50 mm (n = 51) and group 3, AAA > 50 mm (n = 50). TAT (p < 0.001) and D-dimer (p < 0.001) were increased in patients with AAA (groups 2 and 3) vs. group 1.
To assess the association between baseline TAT and D-dimer concentrations, and AAA growth, aortic diameter and volume (volumetry) were measured by computed tomography angiography (CTA) in group 2 at recruitment (baseline) and 1-year after inclusion. Baseline D-dimer and TAT levels were associated with AAA diameter and volume variations at 1-year independently of confounding factors (p ≤ 0.044).
Additionally, surgery incidence, recorded during a 4-year follow-up in group 2, was associated with larger aneurysms, assessed by aortic diameter and volumetry (p ≤ 0.036), and with elevated TAT levels (sub-hazard ratio 1.3, p ≤ 0.029), while no association was found for D-dimer.
The combination of hemostatic parameters and image techniques might provide valuable tools to evaluate AAA growth and worse evolution.