Cytogenetic marker del(12p) in a case of acute myeloid leukemia M4 with eosinophilia and inv(16)
Cigudosa JC, Calasanz MJ, Gullón A, Cuesta B, Rifón J, Rocha E.
Departamento de Genética, Universidad de Navarra, Clínica Universitaria, Pamplona.
A 35-year-old Spanish female having acute myelomonocytic leukaemia with marrow eosinophilia is reported. The karyotype revealed the specific chromosomal abnormality associated with this disorder, inv(16), and a less-specific myelodysplastic cytogenetic marker, del(12p).
We have reviewed the published cases in order to elucidate the possible significance of presenting a 12p deletion (nonrandomly associated with chronic myelomonocytic leukaemia) together with other chromosomal rearrangements.
CITATION Sangre (Barc). 1992 Apr;37(2):125-7