Clinico-pathologic correlation in patients undergoing surgical staging and radical prostatectomy for prostatic cancer
Isa Kroon WA, De Castro Barbosa F, Abad Vivas-Perez JI, Robles García JE, Berián Polo JM.
Departamento de Urología, Clínica Universitaria, Facultad de Medicina, Universidad de Navarra, Pamplona.
Presentation of our experience on the clinico-pathological staging of clinically localized prostate cancer (PCa) in 38 patients undergoing staging lymphadenectomy, 34 of which were treated with radical prostatectomy. From total number of patients, 37% were correctly staged, 60% were under-staged and only 3% were over-staged.
A total of 11 patients (29%) presented nodular metastasis at the time of lymphadenectomy. Out of the 34 patients undergoing radical prostatectomy, 10 (29%) had microscopical invasion of prostatic capsule and seminal vesicles infiltration. The likelihood of nodes affectation in patients with prostatic capsule invasion and seminal vesicles infiltration was 60% and 70%, respectively. Mean PSA was significantly higher in patients with advanced disease as compared to those with disease localized in the prostatic gland.
Also, mean PSA was significantly higher in patients with prostatic capsule invasion and seminal vesicles infiltration. The analysis by logistic regression identified pre-operative PSA as the only variable significantly correlated to the patient's final pathological stage.
CITATION Actas Urol Esp. 1993 Feb;17(2):122-5