Autoimmune Diseases Are Linked to Type IIb Autoimmune Chronic Spontaneous Urticaria
Pavel Kolkhir 1 2 , Sabine Altrichter 1 , Riccardo Asero 3 , Alvaro Daschner 4 , Marta Ferrer 5 , Ana Giménez-Arnau 6 , Tomasz Hawro 1 , Thilo Jakob 7 , Tamar Kinaciyan 8 , Arno Kromminga 9 10 , George N Konstantinou 11 , Michael Makris 12 , Martin Metz 1 , Per Stahl Skov 13 14 , Petra Staubach 15 , Gordon Sussman 16 , Ke Zhang 17 , Marcus Maurer 18
Purpose: Patients with chronic spontaneous urticaria (CSU) have an increased risk for comorbid autoimmune diseases. In this retrospective multicenter study of CSU patients, we evaluated clinical and laboratory features of CSU associated with a higher risk of comorbid autoimmune diseases.
Methods: We analyzed records of CSU patients (n = 1,199) for a history or presence of autoimmune diseases. Patients were diagnosed with type IIb autoimmune CSU (aiCSU) if all 3 tests were positive: autologous serum skin test (ASST), basophil histamine release assay (BHRA) and/or basophil activation test (BAT), and IgG autoantibodies against FcεRIα/IgE detected by immunoassay.
Results: Twenty-eight percent of CSU patients had at least 1 autoimmune disease. The most prevalent autoimmune diseases were Hashimoto's thyroiditis (HT) (≥ 21%) and vitiligo (2%). Two percent of CSU patients had ≥ 2 autoimmune diseases, most frequently HT plus vitiligo. Comorbid autoimmune diseases, in patients with CSU, were associated with female sex, a family history of autoimmune diseases, and higher rates of hypothyroidism and hyperthyroidism (P < 0.001). Presence of autoimmune diseases was linked to aiCSU (P = 0.02). The risks of having autoimmune diseases were 1.7, 2.9 and 3.3 times higher for CSU patients with a positive ASST, BHRA and BAT, respectively. In CSU patients, markers for autoimmune diseases, antinuclear antibodies and/or IgG anti-thyroid antibodies were associated with non-response to omalizumab treatment (P = 0.013).
Conclusions: In CSU, autoimmune diseases are common and linked to type IIb autoimmune CSU. Our results suggest that physicians assess and monitor all adult patients with CSU for signs and symptoms of common autoimmune diseases, especially HT and vitiligo.
CITATION Allergy Asthma Immunol Res. 2021 Jul;13(4):545-559. doi: 10.4168/aair.2021.13.4.545