Scientific publications

Adoptive T-cell therapy with CD45RA-deplected donor in the treatment of cytomegalovirus disease in immunocompromised non-transplant patients

Yuste JR (1,2), Díaz de Cerio AL (3,4), Rifón J (4), Moreno C (3), Panizo M (1), Inogés S (3,4).

(1) Division of Infectious Diseases, Clínica Universidad de Navarra, Pamplona, Spain.
(2) Department of Internal Medicine, Clínica Universidad de Navarra, Pamplona, Spain.
(3) Immunology and Immuotherapy Department, Clínica Universidad de Navarra, Pamplona, Spain.
(4) Hematology Service and Cell Therapy Area, Clínica Universidad de Navarra, Pamplona, Spain.

Magazine: Antiviral Therapy

Date: Mar 26, 2019

Immunology [SP] Cell Therapy Area [SP] Infectious Diseases [SP] Hematología y Hemoterapia [SP]

ABSTRACT

Cytomegalovirus (CMV) infections can induce severe complications in immunosuppressed patients. Currently, ganciclovir represents the preferred treatment option; however, in patients with resistance or toxicity related to ganciclovir, the therapeutic options are limited.Cellular immunity plays an important role in the control of viral infections.

Adoptive T cell therapy can contribute to recovering immunological function in immunosuppressed patients. Selective T cell depletion targeting CD45RA enhances early T cell recovery and can represent a salvage therapy.

In this study, an immunocompromised non-transplanted patient with CMV disease and toxicity to conventional therapy was successfully treated by adoptive transfer of CD45RA-depleted T cells.

CITATION  Antivir Ther. 2019 Mar 26. doi: 10.3851/IMP3307

you mayBE INTERESTED

WHAT TECHNOLOGY
DO WE USE?

The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

OUR
PROFESSIONALS

The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.

Imagen profesionales de la Clínica Universidad de Navarra

WHY CHOOSE
THE CLINICA?

Learn why we are different from other healthcare centers. Quality, speed, comfort and results.

Imagen del edificio de la Clínica Universidad de Navarra