Adoptive T-cell therapy with CD45RA-deplected donor in the treatment of cytomegalovirus disease in immunocompromised non-transplant patients
Yuste JR (1,2), Díaz de Cerio AL (3,4), Rifón J (4), Moreno C (3), Panizo M (1), Inogés S (3,4).
Cytomegalovirus (CMV) infections can induce severe complications in immunosuppressed patients. Currently, ganciclovir represents the preferred treatment option; however, in patients with resistance or toxicity related to ganciclovir, the therapeutic options are limited.Cellular immunity plays an important role in the control of viral infections.
Adoptive T cell therapy can contribute to recovering immunological function in immunosuppressed patients. Selective T cell depletion targeting CD45RA enhances early T cell recovery and can represent a salvage therapy.
In this study, an immunocompromised non-transplanted patient with CMV disease and toxicity to conventional therapy was successfully treated by adoptive transfer of CD45RA-depleted T cells.