Scientific publications
A road map for the treatment of pediatric diffuse midline glioma
Carl Koschmann 1 , Wajd N Al-Holou 2 , Marta M Alonso 3 , Jamie Anastas 4 , Pratiti Bandopadhayay 5 , Tara Barron 6 , Oren Becher 7 , Rodrigo Cartaxo 2 , Maria G Castro 2 , Chan Chung 8 , Madison Clausen 2 , Derek Dang 2 , Robert Doherty 2 , Ryan Duchatel 9 , Matthew Dun 9 , Mariella Filbin 5 , Andrea Franson 2 , Stefanie Galban 2 , Marc Garcia Moure 3 , Hugh Garton 2 , Pruthvi Gowda 5 , Joana Graca Marques 3 , Cynthia Hawkins 10 , Allison Heath 11 , Esther Hulleman 12 , Sunjong Ji 2 , Chris Jones 13 , Lindsay Kilburn 14 , Cassie Kline 11 , Michael A Koldobskiy 15 , Daniel Lim 16 , Pedro R Lowenstein 2 , Q Richard Lu 17 , Joanna Lum 2 , Stephen Mack 18 , Suresh Magge 2 , Bernard Marini 2 , Donna Martin 2 , Neena Marupudi 2 , Dana Messinger 2 , Rajen Mody 2 , Meredith Morgan 2 , Mateus Mota 2 , Karin Muraszko 2 , Sabine Mueller 19 , Siva Kumar Natarajan 2 , Javad Nazarian 20 , Michael Niculcea 2 , Nicholas Nuechterlein 21 , Hideho Okada 16 , Valerie Opipari 2 , Manjunath P Pai 2 , Sharmistha Pal 5 , Erik Peterson 2 , Timothy Phoenix 17 , John R Prensner 2 , Matthew Pun 2 , G Praveen Raju 7 , Zachary J Reitman 22 , Adam Resnick 11 , David Rogawski 6 , Amanda Saratsis 23 , Stefanie G Sbergio 10 , Mark Souweidane 24 , James M Stafford 24 , Theophilos Tzaridis 25 , Sujatha Venkataraman 26 , Orazio Vittorio 27 , Jack Wadden 2 , Daniel Wahl 2 , Robert J Wechsler-Reya 28 , Viveka Nand Yadav 29 , Xu Zhang 28 , Qiang Zhang 2 , Sriram Venneti 30
Abstract
Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise.
We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring.
We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.
CITATION Cancer Cell. 2023 Nov 20:S1535-6108(23)00393-8. doi: 10.1016/j.ccell.2023.11.002
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