Publicaciones científicas
A road map for the treatment of pediatric diffuse midline glioma
Carl Koschmann 1 , Wajd N Al-Holou 2 , Marta M Alonso 3 , Jamie Anastas 4 , Pratiti Bandopadhayay 5 , Tara Barron 6 , Oren Becher 7 , Rodrigo Cartaxo 2 , Maria G Castro 2 , Chan Chung 8 , Madison Clausen 2 , Derek Dang 2 , Robert Doherty 2 , Ryan Duchatel 9 , Matthew Dun 9 , Mariella Filbin 5 , Andrea Franson 2 , Stefanie Galban 2 , Marc Garcia Moure 3 , Hugh Garton 2 , Pruthvi Gowda 5 , Joana Graca Marques 3 , Cynthia Hawkins 10 , Allison Heath 11 , Esther Hulleman 12 , Sunjong Ji 2 , Chris Jones 13 , Lindsay Kilburn 14 , Cassie Kline 11 , Michael A Koldobskiy 15 , Daniel Lim 16 , Pedro R Lowenstein 2 , Q Richard Lu 17 , Joanna Lum 2 , Stephen Mack 18 , Suresh Magge 2 , Bernard Marini 2 , Donna Martin 2 , Neena Marupudi 2 , Dana Messinger 2 , Rajen Mody 2 , Meredith Morgan 2 , Mateus Mota 2 , Karin Muraszko 2 , Sabine Mueller 19 , Siva Kumar Natarajan 2 , Javad Nazarian 20 , Michael Niculcea 2 , Nicholas Nuechterlein 21 , Hideho Okada 16 , Valerie Opipari 2 , Manjunath P Pai 2 , Sharmistha Pal 5 , Erik Peterson 2 , Timothy Phoenix 17 , John R Prensner 2 , Matthew Pun 2 , G Praveen Raju 7 , Zachary J Reitman 22 , Adam Resnick 11 , David Rogawski 6 , Amanda Saratsis 23 , Stefanie G Sbergio 10 , Mark Souweidane 24 , James M Stafford 24 , Theophilos Tzaridis 25 , Sujatha Venkataraman 26 , Orazio Vittorio 27 , Jack Wadden 2 , Daniel Wahl 2 , Robert J Wechsler-Reya 28 , Viveka Nand Yadav 29 , Xu Zhang 28 , Qiang Zhang 2 , Sriram Venneti 30
Abstract
Recent clinical trials for H3K27-altered diffuse midline gliomas (DMGs) have shown much promise.
We present a consensus roadmap and identify three major barriers: (1) refinement of experimental models to include immune and brain-specific components; (2) collaboration among researchers, clinicians, and industry to integrate patient-derived data through sharing, transparency, and regulatory considerations; and (3) streamlining clinical efforts including biopsy, CNS-drug delivery, endpoint determination, and response monitoring.
We highlight the importance of comprehensive collaboration to advance the understanding, diagnostics, and therapeutics for DMGs.
CITA DEL ARTÍCULO Cancer Cell. 2023 Nov 20:S1535-6108(23)00393-8. doi: 10.1016/j.ccell.2023.11.002
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