Scientific publications

A new case of acute lymphoblastic leukemia B-cell type with chromosomal rearrangements involving the T-cell receptor breakpoint at band 14q11

Sep 30, 1992 | Magazine: American Journal of Hematology

Cigudosa JC, Calasanz MJ, Gullón A, Prósper F, Cuesta B, Rifón J, Rocha E.
Department of Genetics, University of Navarra, Pamplona, Spain.

A patient with B-cell acute lymphoblastic leukemia (ALL) and a translocation t(8;14) (q24;q11) is described.

Translocation t(8;14)(q24;q32) is commonly associated with B-cell leukemia; nevertheless, translocations affecting chromosome 14 at band q11 are associated with T-cell malignancies, since the locus 14q11 contains genes that encode for the alpha and delta chains of the T-cell receptor (TCR). This finding points to the idea that the association between 14q11 rearrangements and T-cell neoplasia is less than complete.

CITATION  Am J Hematol. 1992 Oct;41(2):137-9.

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