A comparative study of the pharmacokinetics of ibuprofen arginate versus dexibuprofen in healthy volunteers
Sádaba B, Campanero MA, Muñoz-Juarez MJ, Gil-Aldea I, García-Quetglas E, Esteras A, Azanza JR.
Clinical Research Unit, Clínica Universitaria de Navarra, Universidad de Navarra, 31008, Pamplona, Spain.
Magazine: European Journal of Clinical Pharmacology
Date: Oct 1, 2006Clinical Research Unit [SP] Clinical Pharmacology [SP]
Ibuprofen arginate is a salt formulation of ibuprofen designed to reach target concentrations rapidly. The primary objective of this study was to compare the 12-h pharmacokinetic profile of S(+)-ibuprofen following administration of single doses of ibuprofen arginate (600 mg) and dexibuprofen (400 mg) in healthy volunteers.
Twenty-four volunteers were recruited into an open-label, randomised, two-period, single-centre study with crossover design.
Both treatments were well tolerated. Ibuprofen arginate and dexibuprofen showed similar bioavailability for S(+)-ibuprofen. Compared with dexibuprofen, ibuprofen arginate demonstrated a 45% higher maximum concentration (C(max)), and a time to peak concentration (T(max)) 2 h sooner.
Ibuprofen arginate approaches maximum concentrations of S(+)-ibuprofen faster and higher than dexibuprofen.
CITATION Eur J Clin Pharmacol. 2006 Oct;62(10):849-54
you maybe interested
The Clínica is the greater private hospital with technological equipment of Spain, all in a single center.
The professionals of the Clínica perform continuous research and training, always to the benefit of the patient.
Learn why we are different from other healthcare centers. Quality, speed, comfort and results.