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Clinical trial of the Bcl-2 inhibitor BGB-11417 in patients with mature B-lymphocyte malignancies.
THE OBJECTIVE OF THIS TRIAL IS TO DETERMINE SAFETY AND TOLERABILITY; TO DEFINE THE MAXIMUM TOLERATED DOSE (MTD) AND RECOMMENDED DOSE FOR PHASE II (DRF2); AND TO EVALUATE THE SAFETY AND TOLERABILITY OF THE STEP-UP DOSING SCHEDULE AND DRF2 OF BGB-11417, IN MONOTHERAPY AND IN COMBINATION WITH ZANUBRUTINIB.
Technical Summary
- PHASE I/IB OPEN-LABEL DOSE ESCALATION AND DOSE ESCALATION STUDY OF THE BCL-2 INHIBITOR BGB-11417 IN PATIENTS WITH MATURE B-LYMPHOCYTE MALIGNANCIES
- Code EudraCT: 2020-004641-37
- Protocol number: BGB-11417-101
- Promoter: BeiGene, Ltd.
* The trials only admit a limited number of patients and are subject to inclusion and exclusion criteria. The specialist who assesses your case will inform you of the conditions required to participate in the clinical trial.
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