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Clinical trial of RMC-6291 in monotherapy in subjects with advanced solid tumors with KRAS(G12C) mutation.
THE PURPOSE OF THIS STUDY IS TO EVALUATE THE SAFETY, TOLERABILITY AND PHARMACOKINETICS (PK) OF ESCALATING DOSES OF RMC-6291 (KRAS G12C(ON) INHIBITOR) IN MONOTHERAPY IN ADULT SUBJECTS WITH ADVANCED SOLID TUMORS AND TO IDENTIFY THE MAXIMUM TOLERATED DOSE (MTD) AND RECOMMENDED PHASE 2 DOSE.
Technical Summary
- PHASE I/IB, MULTICENTER, OPEN-LABEL, OPEN-LABEL, STEPWISE ESCALATION AND DOSE ESCALATION STUDY OF RMC-6291 IN MONOTHERAPY IN SUBJECTS WITH ADVANCED KRAS(G12C)-MUTATED SOLID TUMORS
- Code EudraCT: 2022-000388-35
- Protocol number: RMC-6291-001
- Promoter: Revolution Medicines, Inc.
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