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Clinical trial of ro7122290, a 4-1bb (cd137l) ligand directed against fibroblast activation protein A (fap), in combination with cibisatamab, in participants with metastatic colorectal adenocarcinoma.

Status
In recruitment
headquarters
Pamplona

Technical Summary

  • AN OPEN-LABEL, MULTICENTER PHASE IB STUDY TO EVALUATE THE SAFETY, PHARMACOKINETICS, PHARMACODYNAMICS, AND PRELIMINARY ANTITUMOR ACTIVITY OF RO7122290, A 4-1BB (CD137L) LIGAND DIRECTED AGAINST FIBROBLAST ACTIVATION PROTEIN (FAP), IN COMBINATION WITH CIBISATAMAB, WITH PRETREATMENT WITH OBINUTUZUMAB, IN PARTICIPANTS WITH METASTATIC COLORECTAL ADENOCARCINOMA WITH MICROSATELLITE STABILITY AND HIGH CEACAM5 EXPRESSION TREATED PREVIOUSLY. IMMUNOTHERAPY
  • Code EudraCT: 2020-003328-17
  • Protocol number: BP42675
  • Promoter: Roche Farma, S.A.
  • Link to Clinical Trials

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