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Clinical trial to compare ociperlimab plus tislelizumab combined with qRTs)followed by ociperlimab plus tislelizumab or tislelizumab plus qRTs followed by tislelizumab versus qRTs followed by durvalumab in patients with non-small cell lung cancer.
THE AIM OF THIS STUDY IS TO EVALUATE THE SAFETY, EFFICACY, BENEFIT AND RISKS OF INVESTIGATIONAL ANTICANCER DRUGS CALLED TISLELIZUMAB (ALSO CALLED BGB-A317) PLUS OCIPERLIMAB (ALSO CALLED BGB-A1217) IN COMBINATION WITH SIMULTANEOUS CHEMORADIOTHERAPY (CRTS), VERSUS TISLELIZUMAB IN COMBINATION WITH CRTS, VERSUS DURVALUMAB WITH CRTS, TO FIND OUT WHICH TREATMENT IS MORE BENEFICIAL FOR NSCLC.
Technical Summary
- PHASE III, RANDOMIZED, OPEN-LABEL STUDY TO COMPARE OCIPERLIMAB (BGB-A1217) PLUS TISLELIZUMAB (BGB-A317) COMBINED WITH CONCURRENT CHEMORADIOTHERAPY (CRTS) FOLLOWED BY OCIPERLIMAB PLUS TISLELIZUMAB OR TISLELIZUMAB PLUS CRTS FOLLOWED BY TISLELIZUMAB VERSUS CRTS FOLLOWED BY DURVALUMAB IN PATIENTS WITH UNRESECTABLE, LOCALLY ADVANCED, PREVIOUSLY UNTREATED NON-SMALL-CELL LUNG CANCER. IMMUNOTHERAPY.
- Code EudraCT: 2020-004656-14
- Protocol number: BGB-A317-A1217-301
- Promoter: BeiGene USA, Inc.
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