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Study of OMTX705 in combination with regorafenib and tislelizumab in patients with advanced or metastatic colorectal cancer
THE OBJECTIVE OF THIS TRIAL IS TO TEST WHETHER A NEW DRUG, OMTX705, IS SAFE AND WELL TOLERATED WHEN USED IN CONJUNCTION WITH TWO OTHER EXISTING DRUGS: REGORAFENIB (STIVARGA®) AND TISLELIZUMAB (TEVIMBRA®), AND TO DETERMINE THE MOST APPROPRIATE DOSE OF THESE DRUGS FOR USE IN FUTURE TRIALS AND FURTHER CLINICAL DEVELOPMENT OF OMTX705.
Technical Summary
- PHASE 1B/2 DOSE ESCALATION STUDY OF OMTX705, A DRUG-CONJUGATED ANTIBODY AGAINST FIBROBLAST ACTIVATION PROTEIN, IN COMBINATION WITH REGORAFENIB AND TISLELIZUMAB IN PATIENTS WITH ADVANCED OR METASTATIC COLORECTAL CANCER.
- Code EudraCT: 2025-520743-33
- Protocol number: OMTX705-004
- Promoter: Oncomatryx Biopharm S.L.
- Molecule/Drug: OMTX705
* The trials only admit a limited number of patients and are subject to inclusion and exclusion criteria. The specialist who assesses your case will inform you of the conditions required to participate in the clinical trial.

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