Clinical trials
for patients
Learn about available clinical trials
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April 15, 2026Pamplona/MadridIn recruitmentEarly phase
EXS73565-001 A Phase I, open-label, multicenter, dose-escalation clinical trial to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of EXS73565 in participants with lymphocytic malignancies.
The purpose of this clinical trial is to investigate the drug’s safety, how well you tolerate the drug, and its antitumor activity, and to determine the optimal dose when administered daily as an oral tablet. -
April 14, 2026Pamplona/MadridIn recruitment
RPTR-1-201-101 Phase I/II clinical trial of RPTR-1-201, a bispecific T-cell receptor therapy, in patients with advanced solid tumors.
The main goal of this clinical research trial is to determine whether the investigational drug, RPTR-1-201, is safe and what side effects it may cause. In some parts of the trial, RPTR-1-201 will be given alone, and in other parts, it will be given together with another cancer drug called pembrolizumab. The goal is to assess the safety of RPTR-1-201 when used alone and when used together with pembrolizumab. -
April 14, 2026Pamplona/MadridIn recruitment
BNT327-05 A Phase III, multicenter, randomized, double-blind clinical trial of BNT327 in combination with chemotherapy versus placebo plus chemotherapy in patients with triple-negative breast cancer (TNBC).
The aim of this study is to compare the effects of the study drug, pumitamig (also known as BNT327 or PM8002), with those of a placebo, when both are administered in combination with chemotherapy. -
April 7, 2026Pamplona/MadridIn recruitment
DS6000-109 Clinical trial to evaluate raludotatug deruxtecan (R-DXd) in participants with rapidly progressing ovarian cancer, primary peritoneal cancer, or platinum-resistant fallopian tube cancer.
The primary objective is to evaluate raludotatug deruxtecan, also known as R-DXd, at each dose level. -
April 7, 2026PamplonaIn recruitment
AMICO Exploring the Anti-Aging Effects of Metformin in COPD
The primary objectives of this study are to investigate whether taking metformin slows the loss of lung function and halts the progression of emphysema (lung damage). We also want to explore whether some of the conditions associated with aging and very common in patients with this disease—such as cancers (especially lung cancer), angina, heart attacks, or kidney damage—can be prevented by taking metformin. -
April 6, 2026Pamplona/MadridIn recruitment
GRWD5769-ST-01 A study focusing on the ERAP-1-mediated immunopeptidome.
The primary objective of this clinical trial is to determine the safety and efficacy of the study drug 12GRWD5769, either alone or in combination with another drug called Libtayo® (cemiplimab), in the treatment of advanced or metastatic solid tumors. -
April 6, 2026Pamplona/MadridIn recruitmentEarly phase
GEM-CAR-HIRISMM A Phase II, open-label, single-arm, multicenter study of Ciltacabtagene Autoleucel in high-risk quiescent multiple myeloma
The aim of this study is to investigate the safety and efficacy of the Dara-VRD regimen followed by Ciltacabtagene autoleucel (cilta-cel), a CAR-T therapy, in patients diagnosed with high-risk MMq. -
March 31, 2026PamplonaIn recruitmentEarly phase
CPV-104-101 A Phase 1 clinical trial in humans involving healthy participants and patients with C3 glomerulopathy to evaluate the safety, tolerability, and pharmacokinetics of CPV-104.
The purpose of this study is to determine whether CPV-104 (the drug being studied) is safe for use in people (safety), the manageability of side effects (tolerability), the blood concentrations of CPV-104 and factor H (an important protein in the human body involved in the immune system) in the blood (pharmacokinetics), and whether CPV-104 triggers a defensive reaction in the body against foreign substances (immunogenicity). -
March 24, 2026Pamplona/MadridIn recruitment
BNT326-02 A Phase Ib/II, multicenter, open-label clinical trial to evaluate the safety, efficacy, and pharmacokinetics of BNT326 in combination with BNT327 in participants with advanced non-small cell lung cancer.
The purpose of this trial is: to investigate a potential new combination of trial drugs (consisting of the trial drug, which is an antibody-drug conjugate [ADC] called BNT326, in combination with an immunotherapy drug, BNT327) to determine the recommended dose of the trial drug; to evaluate the safety of the combination of study drugs; and to obtain information on its efficacy for advanced or metastatic NSCLC. -
March 24, 2026Pamplona/MadridIn recruitment
18-BI-1206-03 A Phase I/IIa clinical trial of BI-1206, a monoclonal antibody targeting CD32b (Fc?RIIB), in combination with pembrolizumab, in patients with advanced solid tumors.
The aim is to determine whether the drug BI-1206, which has not yet been approved for marketing, will be effective in treating advanced solid tumors and how safe it is for people. In this study, BI-1206 will be administered in combination with pembrolizumab, an approved drug marketed as Keytruda