Immunotherapy Centres of Research Excellence (imCORE) Network

Development of research for the treatment of oncological diseases through immunotherapy

The Clínica Universidad de Navarra is one of the 27 health institutions worldwide which form part of the ImCORE network of centers of excellence in cancer immunotherapy. In Spain, at present, in addition to the Clinic, only the Vall d'Hebron hospital participates in this research program in cancer immunotherapy.

ImCORE is a research network promoted by the pharmaceutical company Roche-Genentech (Basel-San Francisco) with the aim of bringing together the main centers of excellence in immuno-oncology around the world to collaborate in the search for innovative approaches in this line of hematooncology treatments. The Laboratory assists in the financing and development of research for the treatment of hematooncological diseases through immunotherapy, favoring the collaboration of the participating centers.

Imagen del icono de la consulta de Segunda Opinión. Clínica Universidad de Navarra

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Participation of the Clinic

Since 2016, the year in which the Clinic joined imCORE, 5 studies of its own have been promoted (one already developed), accepted by the network, three are pre-clinical projects and two are clinical trials. Promoted by Roche/Genentech, through imCORE, the Clinic is currently participating in a total of 11 clinical trials whose principal investigator is Dr. Ignacio Melero (Immunotherapy and Immunology).

Within this line of research promoted by Roche, there is a specific branch of studies called 'Morpheus', in which an innovative strategy is used to speed up the testing of combinations of immunotherapy drugs in a selection of tumors such as pancreas, stomach, lung or breast. Through the imCORE program, the aim is to boost laboratory research associated with these complex clinical studies.

<p>Imagen Dr. Ignacio Melero Bermejo, Inmunología</p>

"Collaboration in a network of these characteristics also allows the center to be in contact with other institutions and their lines of research, facilitating the initiation of clinical or preclinical proposals, as well as enabling their patients to quickly access new therapies".

Co-Director of the Immunology Service

Learn about cancer immunotherapy

Immunotherapy is a modality of biological therapy against cancer based on the active or passive stimulation of the patient's own immune system.

There are different types of immunotherapy, although in general its function is to counteract the ability of tumors to deactivate the patient's immune system.

Among the different categories, the main ones are:

  • Monoclonal antibodies.
  • Non-specific immunotherapies.
  • Therapies with oncolytic virus.
  • Therapies with T cells (CAR-T).
  • Vaccines against cancer.
Miniatura del infográfico sobre inmunoterapia y cáncer. Clínica Universidad de Navarra

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Goals and Benefits of the ImCore Network

Imagen de un icono azul de un microscopio dentro de un círculo.

Agility in research projects to enhance speed

Working in "super groups" in order to shorten the time needed for new drugs to reach patients and advance knowledge of immuno-oncology

Imagen de un icono azul que simboliza el trabajo en equipo.

Promote scientific collaboration among the 27 centers

Rapid initiation of research arising from the latest scientific discoveries and sharing of data that will accelerate the search for new forms of treatment

Imagen de un icono azul de un equipo de profesionales dentro de un círculo.

Offer accessible treatment to more patients

Expand the number of people who can benefit from immunotherapy as a treatment for cancer, exploring new formulas that can activate the immune system in this way