Publicaciones científicas

Ultrasound for assessing tumor spread in ovarian cancer. A systematic review of the literature and meta-analysis

18-nov-2023 | Revista: European Journal of Obstetrics, Gynecology and Reproductive Biology

Juan Luis Alcázar  1 , Juan Ramón Pérez-Vidal  2 , Sarah Tameish  3 , Enrique Chacón  4 , Nabil Manzour  4 , José Ángel Mínguez  4


In this review, we aimed to assess the diagnostic performance of ultrasound for assessing the tumor spread in the abdomen in women with ovarian cancer. A search for studies evaluating the role of ultrasound for assessing intrabdominal tumor spread in women with ovarian cancer compared to surgery from January 2011 to March 2023 was performed in PubMed/MEDLINE, Web of Science, and Scopus databases.

The Quality Assessment of Diagnostic Accuracy Studies 2 evaluated the quality of the studies (QUADAS-2). All analyses were performed using MIDAS and METANDI commands in STATA 12.0 software. We identified 1552 citations. After exclusions, five studies comprising 822 women were included.

Quality of studies were considered as good, except for patient selection as all studies were considered as having high risk of bias. The pooled sensitivity and specificity could be calculated for three anatomical areas (recto-sigma, major omentum and root of mesentery) and the presence of ascites.

The pooled sensitivity and specificity for detecting disease in the recto-sigma, major omentum and root of mesentery were 0.83 and 0.95, 0.87 and 0.87, and 0.29 and 0.99, respectively. The pooled sensitivity and specificity for detecting ascites was 0.95 and 0.91, respectively.

There is evidence that ultrasound offers good diagnostic performance for evaluating the intra-abdominal extent of disease in women with suspected ovarian cancer.

CITA DEL ARTÍCULO  Eur J Obstet Gynecol Reprod Biol. 2023 Nov 18:292:194-200. doi: 10.1016/j.ejogrb.2023.11.017