The subthalamic nucleus: a possible target for stereotaxic surgery in Parkinson's disease
Guridi J, Luquin MR, Herrero MT, Obeso JA.
Movement Disorders Unit, Clinica Universitaria, Pamplona, Spain.
Hyperactivity in the subthalamic nucleus (STN) projections to the globus pallidus medialis (GPM) has been established as a crucial feature of parkinsonism in animal models of Parkinson's disease (PD). Recent experiments blocking the STN glutamatergic output to GPM or lesioning the STN support this concept by showing a dramatic reversal of parkinsonism.
We review the role of stereotaxic surgery in the past and the possible future application of subthalamotomy for PD.
CITA DEL ARTÍCULO Mov Disord. 1993 Oct;8(4):421-9