Publicaciones científicas

The role of sex and gender in the diagnosis and treatment of lung cancer: the 6th ICAPEM Annual Symposium

25-jul-2023 | Revista: Clinical & Translational Oncology

Nuria Viñolas  1 , Laura Mezquita  2 , Jesús Corral  3 , Manuel Cobo  4 , Francisco Gil-Moncayo  5 , Luis Paz-Ares  6 , Jordi Remon  7 , María Rodríguez  8 , Alberto Ruano-Raviña  9 , Esther Conde  10 , Margarita Majem  11 , Pilar Garrido  12 , Enriqueta Felip  13 , Dolores Isla  14 , Javier de Castro  15


The incidence and mortality of lung cancer in women are rising, with both increasing by 124% between 2003 and 2019. The main risk factor for lung cancer is tobacco use, but indoor radon gas exposure is one of the leading causes in nonsmokers.

The most recent evidence demonstrates that multiple factors can make women more susceptible to harm from these risk factors or carcinogens. For this consensus statement, the Association for Lung Cancer Research in Women (ICAPEM) invited a group of lung cancer experts to perform a detailed gender-based analysis of lung cancer.

Clinically, female patients have different lung cancer profiles, and most actionable driver alterations are more prevalent in women, particularly in never-smokers. Additionally, the impact of certain therapies seems to be different.

In the future, it will be necessary to carry out specific studies to improve the understanding of the role of certain biomarkers and gender in the prognosis and evolution of lung cancer.

CITA DEL ARTÍCULO  Clin Transl Oncol. 2023 Jul 25.  doi: 10.1007/s12094-023-03262-x