Successful thalamic deep brain stimulation for orthostatic tremor
Jorge Guridi, (1,2,3), Maria C. Rodriguez-Oroz, (1,2,3), Javier Arbizu (4), Manuel Alegre (1,2), Elena Prieto(4), Ignacio Landecho (5), Miguel Manrique(1), Julio Artieda (1,2) and Jose A. Obeso (1,2,3)
We report a patient with severe orthostatic tremor (OT) unresponsive to pharmacological treatments that was successfully controlled with thalamic (Vim, ventralis intermedius nucleus) deep brain stimulation (DBS) over a 4-year period.
Cortical activity associated with the OT revealed by EEG back-averaging and fluoro-deoxi-glucose PET were also suppressed in parallel with tremor arrest.
This case suggests that Vim-DBS may be a useful therapeutic approach for patients highly disabled by OT.
CITA DEL ARTÍCULO Mov Disord. 2008 Oct 15;23(13):1808-11