Publicaciones científicas

Single anastomosis duodeno-ileal bypass with sleeve gastrectomy generates sustained improvement of glycemic control compared with sleeve gastrectomy in the diet-induced obese rat model

07-nov-2023 | Revista: Journal of Physiology and Biochemistry

Sara Becerril  1   2   3 , Javier A Cienfuegos  4   5 , Amaia Rodríguez  6   4   7 , Victoria Catalán  6   4   7 , Beatriz Ramírez  6   4   7 , Víctor Valentí  4   5 , Rafael Moncada  4   8 , Xabier Unamuno  6   4   9 , Javier Gómez-Ambrosi  6   4   7 , Gema Frühbeck  10   11   12   13


Bariatric surgery has become a recognized and effective procedure for treating obesity and type 2 diabetes (T2D). Our objective was to directly compare the caloric intake-independent effects of sleeve gastrectomy (SG) and single anastomosis duodenoileal bypass with SG (SADI-S) on glucose tolerance in rats with diet-induced obesity (DIO) and to elucidate the differences between bariatric surgery and caloric restriction.

A total of 120 adult male Wistar rats with DIO and insulin resistance were randomly assigned to surgical (sham operation, SG, and SADI-S) and dietary (pair-feeding the amount of food eaten by animals undergoing the SG or SADI-S surgeries) interventions.

Body weight and food intake were weekly monitored, and 6 weeks after interventions, fasting plasma glucose, oral glucose and insulin tolerance tests, plasma insulin, adiponectin, GIP, GLP-1, and ghrelin levels were determined.The body weight of SADI-S rats was significantly (p < 0.001) lower as compared to the sham-operated, SG, and pair-fed groups.

Furthermore, SADI-S rats exhibited decreased whole body fat mass (p < 0.001), lower food efficiency rates (p < 0.001), and increased insulin sensitivity, as well as improved glucose and lipid metabolism compared to that of the SG and pair-fed rats.SADI-S was more effective than SG, or caloric restriction, in improving glycemic control and metabolic profile, with a higher remission of insulin resistance as well as long-term weight loss.

CITA DEL ARTÍCULO  J Physiol Biochem. 2023 Nov 7.  doi: 10.1007/s13105-023-00993-x