Publicaciones científicas

Segmental Pneumonitis after Radioembolization

01-sep-2018 | Revista: Journal of Vascular and Interventional Radiology

José I Bilbao Jaureguizar  1 , Lidia Sancho  2 , María Páramo  1 , Macarena Rodríguez-Fraile  2 , Ana Chopitea  3 , Alberto Benito  4 , Mercedes Iñarrairaegui  5 , Bruno Sangro  5

Radiation pneumonitis, although infrequent, is a dreaded complication of radioembolization (RE) with yttrium-90 (90Y) microspheres ( 1 ). Only 6 cases have been reported so far ( 1 , 2 ).

It develops when 90Y microspheres reach the lung filter owing to circumvention of the liver sinusoidal network through the tumor or arteriovenous channels. Risk of pneumonitis increases when the lung shunt fraction is > 20% or when the estimated absorbed dose by the lungs is > 30 Gy ( 3 ).

During 90Y RE, occlusion of extrahepatic arterial branches that feed the tumor from the systemic vasculature is commonly performed with the aim to redistribute tumor afferents and administer the treatment through the hepatic arteries. The most common extrahepatic vessel occluded is the right inferior phrenic artery (RIPA) ( 4 , 5 ).

CITA DEL ARTÍCULO  J Vasc Interv Radiol. 2018 Sep;29(9):1305-1306. doi: 10.1016/j.jvir.2018.04.010.