Publicaciones científicas

Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network

19-ago-2020 | Revista: Leukemia

Heinz Ludwig  1 , Mario Boccadoro  2 , Philippe Moreau  3 , Jesus San-Miguel  4 , Michele Cavo  5 , Charlotte Pawlyn  6 , Sonja Zweegman  7 , Thierry Facon  8 , Christoph Driessen  9 , Roman Hajek  10 , Melitios A Dimopoulos  11 , Francesca Gay  2 , Hervé Avet-Loiseau  12 , Evangelos Terpos  11 , Niklas Zojer  13 , Mohamad Mohty  14 , Maria-Victoria Mateos  15 , Hermann Einsele  16 , Michel Delforge  17 , Jo Caers  18 , Katja Weisel  19 , Graham Jackson  20 , Laurent Garderet  21 , Monika Engelhardt  22 , Niels van de Donk  7 , Xavier Leleu  23 , Hartmut Goldschmidt  24 , Meral Beksac  25 , Inger Nijhof  7 , Niels Abildgaard  26 , Sara Bringhen  2 , Pieter Sonneveld  27


Abstract

Vaccination is one of the most successful medical interventions that has saved the life of millions of people. Vaccination is particularly important in patients with multiple myeloma, who have an increased risk of infections due to the disease-inherent immune suppression, and because of the immune suppressive effects of therapy.

Hence, all appropriate measures should be exploited, to elicit an effective immune response to common pathogens like influenza, pneumococci, varicella zoster virus, and to those bacteria and viruses (haemophilus influenzae, meningococci, and hepatitis) that frequently may pose a significant risk to patients with multiple myeloma.

Patients after autologous, and specifically after allogeneic transplantation have severely reduced antibody titers, and therefore require a broader spectrum of vaccinations.

Response to vaccination in myeloma often is less vigorous than in the general population, mandating either measurement of the postvaccination antibody titers and/or repeating the vaccination. Here, we compile the existing data on vaccination in multiple myeloma and provide recommendations for clinical practice.

CITA DEL ARTÍCULO  Leukemia . 2020 Aug 19. doi: 10.1038/s41375-020-01016-0

Nuestros autores