Publicaciones científicas
Ratios of proteins in cerebrospinal fluid in Parkinson's disease cognitive decline: prospective study
Delgado-Alvarado M (1), Dacosta-Aguayo R (1,2), Navalpotro-Gómez I 1,2, Gago B (1,2), Gorostidi A (1,2,3), Jiménez-Urbieta H (1,2), Quiroga-Varela A (1,2,4), Ruiz-Martínez J (1,2,5), Bergareche A (1,2,5), Rodríguez-Oroz MC (1,2,4,5,6,7).
BACKGROUND:
There is a need for biomarkers of dementia in PD.
OBJECTIVES:
To determine if the levels of the main CSF proteins and their ratios are associated with deterioration in cognition and progression to dementia in the short to mid term.
METHODS:
The Parkinson's Progression Markers Initiative database was used as an exploratory cohort, and a center-based cohort was used as a replication cohort. Amyloid ß1-42, total tau, threonine-181 phosphorylated tau, and α-synuclein in the CSF and the ratios of these proteins were assessed.
RESULTS:
In the Parkinson's Progression Markers Initiative cohort (n = 281), the total tau/amyloid ß1-42, total tau/α-synuclein, total tau/amyloid ß1-42+α-synuclein, and amyloid ß1-42/total tau ratios were associated with a risk of progression to dementia over a 3-year follow-up. In the replication cohort (n = 40), the total tau/α-synuclein and total tau/amyloid ß1-42+α-synuclein ratios were associated with progression to dementia over a 41-month follow-up.
CONCLUSION:
Ratios of the main proteins found in PD patient brain inclusions that can be measured in the CSF appear to have value as short- to mid-term predictors of dementia.
CITA DEL ARTÍCULO Mov Disord. 2018 Nov 13. doi: 10.1002/mds.27518.
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