No Lewy pathology in monkeys with over 10 years of severe MPTP Parkinsonism
Glenda Halliday (1), María Trinidad Herrero (2), Karen Murphy (1), Heather McCann (1), Francisco Ros-Bernal (2), Carlos Barcia (2), Hideo Mori (3), Francisco J. Blesa (4), José A. Obeso (4)
(1) Prince of Wales Medical Research Institute and School of Medical Sciences, Faculty of Medicine University of New South Wales, Sydney, Australia
(2) Experimental Neuroscience, Department of Anatomy, Medical School, University of Murcia and CIBERNED, Murcia, Spain
(3) Department of Neurology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan
(4) Department of Neurology and Neuroscience Division, Clínica Universitaria and Medical School, Neuroscience Center, CIMA and CIFA, University of Navarra and CIBERNED, Pamplona, Spain
The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve.
To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased alpha-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation.
This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific.
CITA DEL ARTÍCULO Mov Disord. 2009 Jul 30;24(10):1519-23