Publicaciones científicas

Molecular features in a biphenotypic small cell sarcoma with neuroectodermal and muscle differentiation

01-feb-1998 | Revista: Human Pathology

de Alava E, Lozano MD, Sola I, Panizo A, Idoate MA, Martínez-Isla C, Forteza J, Sierrasesúmaga L, Pardo-Mindán FJ.

We report a case of a 13-year-old girl with soft tissue sarcoma of the hand, which showed muscle and neuroectodermal immunophenotypes. Molecular studies were performed on RNA collected from fine-needle aspiration (FNA) cytology and peripheral blood samples by nested reverse transcriptase-polymerase chain reaction (RT-PCR) and Southern blot analysis.

This biphenotypic tumor showed simultaneous expression of EWS-FLI1 and PAX3-FKHR transcripts, specific of Ewing family tumors and alveolar rhabdomyosarcoma, respectively. Although childhood sarcomas with simultaneous muscle and neural differentiation have been described to have EWS-FLI1 transcripts, there are no reports of tumors with both transcripts.

Cytological specimens are a good source of RNA for molecular studies.

CITA DEL ARTÍCULO  Hum Pathol. 1998 Feb;29(2):181-4