Publicaciones científicas

Management and outcomes of cancer patients with venous thromboembolism presenting with thrombocytopenia

10-jul-2020 | Revista: Thrombosis Research

Ramón Lecumberri  1 , Pedro Ruiz-Artacho  2 , Javier Trujillo-Santos  3 , Benjamin Brenner  4 , Giovanni Barillari  5 , Justo Ruiz-Ruiz  6 , Manuel A Lorente  7 , Peter Verhamme  8 , Fernando Javier Vázquez  9 , Ido Weinberg  10 , Manuel Monreal  11 , RIETE Investigators

(1) Hematology Service, Clínica Universidad de Navarra, CIBERCV, Pamplona, Spain.
(2) Department of Internal Medicine, Clínica Universidad de Navarra, Madrid, Spain.
(3) Department of Internal Medicine, Hospital General Universitario Santa Lucía, Murcia, Spain.
(4) Department of Haematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.
(5) Department of Internal Medicine, Ospedale S. Maria della Misericordia, Udine, Italy.
(6) Department of Internal Medicine, Hospital Universitario de Fuenlabrada, Madrid, Spain.
(7) Department of Internal Medicine, Hospital Vega Baja de Orihuela, Alicante, Spain.
(8) Vascular Medicine and Haemostasis, University of Leuven, Leuven, Belgium.
(9) Department of Internal Medicine, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
(10) Vascular Medicine, Division of Cardiology, Fireman Vascular Center, Massachusetts General Hospital, Boston, USA.
(11) Department of Internal Medicine, Hospital Germans Trias i Pujol, Universidad Católica de Murcia, Badalona, Barcelona, Spain.

Introduction: Treatment of venous thromboembolism (VTE) in cancer patients with thrombocytopenia is challenging due to perceived higher risk of bleeding.

Material and methods: We used the RIETE registry to compare the 10- and 30-day outcomes in cancer patients with acute VTE, according to platelet count at baseline.

Results: As of December 2018, 15,337 cancer patients with VTE were included: 166 (1.1%) had <50 × 109 platelets/L (severe thrombocytopenia), 711 (4.6%) had 50-99 × 109/L (mild thrombocytopenia) and 14,460 (94.3%) had ≥100 × 109/L (normal count). Most patients in all subgroups received initial therapy with low-molecular-weight heparin (LMWH), but 62% of those with severe thrombocytopenia received <150 IU/kg/day LMWH, 42% received <100 IU/kg/day.

The mortality rate progressively decreased with increasing platelet counts (12%, 9.4% and 3.3% respectively at 10 days, 27%, 18% and 9.4% at 30 days), but the major bleeding rates did not (1.2%, 2.5% and 1.3% respectively at 10 days, 2.4%, 4.4% and 2.2% at 30 days).

On multivariable analysis, patients with severe thrombocytopenia had a similar risk for major bleeding at 10 days (OR 0.84; 95%CI 0.20-3.49) and at 30 days (OR 0.90; 95%CI 0.32-2.49), but those with mild thrombocytopenia were at increased risk both at 10 days (OR 2.11; 95%CI 1.27-3.49) and at 30 days (OR 1.91; 95%CI 1.29-2.84).

Conclusions: Cancer patients with acute VTE and baseline thrombocytopenia often receive initial lower-than recommended doses of LMWH. Although caution is required, this practice seems to be safe in patients with severe thrombocytopenia. Nonetheless, there was an inverse correlation between baseline platelet count and mortality.

CITA DEL ARTÍCULO  Thromb Res. 2020 Jul 10;195:139-145.
doi: 10.1016/j.thromres.2020.07.021