Publicaciones científicas

Immune mediated colitis caused by lung cancer treatment with atezolizumab

01-dic-2017 | Revista: Revista Española de Enfermedades Digestivas

Santiago González Vázquez  1 , Susana de la Riva Onandía  2 , José Ignacio Echeveste  3 , Miguel Muñoz Navas  4


Atezolizumab is an IgG1 isotype monoclonal antibody against the protein programmed cell death-ligand 1 (PD- L1). PD-L1 may be highly expressed in some tumors and is believed to inhibit immune cells that recognize and attack tumor cells. Inhibition of PD-L1 can remove its inhibitory effect and provoke an anti-tumor response.

In October 2016, the Food and Drugs Administration (FDA) approved atezolizumab for the treatment of patients with metastatic non-small cell lung cancer after disease progression during or following platinum based chemotherapy.

We present the case of a 43-year-old male with stage IV lung adenocarcinoma in progression, despite standard chemotherapy.

CITA DEL ARTÍCULO  Rev Esp Enferm Dig. 2017 Dec;109(12):863-864. doi: 10.17235/reed.2017.5060/2017