Publicaciones científicas

Growth factors and mitogenic activity in experimental hypercholesterolemia
García Bolao I., Merino J., Gil M.J., Martínez A., Grau A., Alegría E., Martínez-Caro D.
Departamento de Cardiología, Facultad de Medicina, Universidad de Navarra, Pamplona.
Revista: Revista Española de Cardiología
Fecha: 01-dic-1996
Inmunología e Inmunoterapia Bioquímica Clínica CardiologíaINTRODUCTION
Hypercholesterolemia is associated with increased platelet reactivity and changes in megakaryopoiesis, which might influence the synthesis of growth factors in the megakaryocyte.
MATERIAL AND METHODS
20 miniature pigs were randomly assigned to received 18 weeks of either regular pig chow feed (control group, n = 10) or a high cholesterol diet (cholesterol group, n = 10). Platelet count, mean platelet volume, platelet distribution width and bleeding time were determined in both groups. Intraplatelet and serum mitogenic activity was quantified by Swiss 3T3 and vascular smooth muscle cells proliferation assays. Insulin-like growth factor I and platelet-derived growth factor (BB isoform) levels were quantified in platelet lysates and in serum in both groups.
RESULTS
Hypercholesterolemia was associated to a significant decrease in mean platelet volume and bleeding time, but it did not affect the proliferative effect of serum and platelet lysates nor its growth factor content.
CONCLUSIONS
Taken together, our results suggest that although hypercholesterolemia affects platelet reactivity, its atherosclerosis-promoting effects cannot be explained by a direct effect on vascular smooth muscle cell proliferation or by changes in serum or intraplatelet growth factor content.
CITA DEL ARTÍCULO Rev Esp Cardiol. 1996 Dec;49(12):899-905
tal vezLE INTERESE
¿QUÉ TECNOLOGÍA UTILIZAMOS?
La Clínica es el hospital privado con mayor dotación tecnológica de España, todo en un único centro.

NUESTROS
PROFESIONALES
Los profesionales de la Clínica realizan una labor continuada de investigación y formación, siempre en beneficio del paciente.

POR QUÉ VENIR
A LA CLÍNICA
Conozca por qué somos diferentes a otros centros sanitarios. Calidad, rapidez, comodidad y resultados.
