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Dopamine agonists suppress visual-cortical reflex myoclonus

01-dic-1985 | Revista: Journal of Neurology, Neurosurgery and Psychiatry

Obeso JA, Artieda J, Tuñón T, Luquin MR, Martínez Lage JM.
From the Movement Disorders Unit, Department of Neurology, Clinica Universitaria, University of Navarra, Pamplona, Spain.

Two patients with a diagnosis of olivo-ponto-cerebellar atrophy developed cortical reflex myoclonus to visual (flash) and somaesthetic stimuli.

Oral treatment with levodopacarbidopa (1000/100 mg) or subcutaneous administration of apomorphine (1 mg) abolished the visually-triggered myoclonus, without modifying reflex myoclonus to electrical or tactile stimulation. Intravenous administration of lisuride (0.1 mg) produced a marked reduction in both types of reflex myoclonus.

These results indicate a selective inhibitory effect of dopamine agonist drugs on visual reflex myoclonus of cortical origin.

CITA DEL ARTÍCULO  J Neurol Neurosurg Psychiatry. 1985 Dec;48(12):1277-83

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