Publicaciones científicas

Consensus guide on prophylactic gonadectomy in different sex development

01-oct-2022 | Revista: Endocrinología, Diabetes y Nutrición

Julio Guerrero-Fernández  1 , Pilar González-Peramato  2 , AmaiaRodríguez Rodríguez Estévez  3 , María José Alcázar Villar  4 , Laura Audí Parera  5 , María Cristina Azcona San Julián  6 , Atilano Carcavilla Urquí  7 , Luis Antonio Castaño González  8 , José María Martos Tello  9 , Cristina Mora Palma  7 , Maria Francisca Moreno Macián  10 , Diego Yeste Fernández  11 , Manuel Nistal  12


The risk of suffering from gonadal germ cell tumors (GCT) is increased in some patients with different sexual development (DSD), mainly in those with Y chromosome material.

This risk, however, varies considerably depending on a multitude of factors that make the decision for prophylactic gonadectomy extremely difficult.

In order to make informed recommendations on the convenience of this procedure in cases where there is potential for malignancy, this consensus guide evaluates the latest clinical evidence, which is generally low, and updates the existing knowledge in this field.

CITA DEL ARTÍCULO  Endocrinol Diabetes Nutr (Engl Ed). 2022 Oct;69(8):629-645. doi: 10.1016/j.endien.2022.10.002.  Epub 2022 Nov 8.