Consensus guide on prophylactic gonadectomy in different sex development
Julio Guerrero-Fernández 1 , Pilar González-Peramato 2 , AmaiaRodríguez Rodríguez Estévez 3 , María José Alcázar Villar 4 , Laura Audí Parera 5 , María Cristina Azcona San Julián 6 , Atilano Carcavilla Urquí 7 , Luis Antonio Castaño González 8 , José María Martos Tello 9 , Cristina Mora Palma 7 , Maria Francisca Moreno Macián 10 , Diego Yeste Fernández 11 , Manuel Nistal 12
The risk of suffering from gonadal germ cell tumors (GCT) is increased in some patients with different sexual development (DSD), mainly in those with Y chromosome material.
This risk, however, varies considerably depending on a multitude of factors that make the decision for prophylactic gonadectomy extremely difficult.
In order to make informed recommendations on the convenience of this procedure in cases where there is potential for malignancy, this consensus guide evaluates the latest clinical evidence, which is generally low, and updates the existing knowledge in this field.