Clonal transmission of NDM-5-producing Escherichia coli belonging to high-risk sequence type ST405
Barrado L (1), Pérez-Vázquez M (2), Luis Del Pozo J (3), Martín-Salas C (4), Leiva J (5), Mazón A (4), Ezpeleta C (4), Oteo J (6).
Carbapenemase-producing Enterobacteriaceae are a critical public-health problem. The European Survey on Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) reported that 19% of carbapenem-non-susceptible Escherichia coli isolates produced carbapenemases .
In Spain, an upward trend in carbapenemase-producing E. coli has been observed, mainly due to the dissemination of OXA-48 ; however, sporadic occurrence of NDM-producers has been reported  ; .
The success of high-risk E. coli clones might be due to factors such as increased transmission and colonisation capacity, antibiotic multiresistance and enhanced virulence.