Burden and attitude to resistant and refractory migraine: a survey from the European Headache Federation with the endorsement of the European Migraine & Headache Alliance
Simona Sacco 1 2 , Christian Lampl 3 , Antoinette Maassen van den Brink 4 , Valeria Caponnetto 5 6 , Mark Braschinsky 7 , Anne Ducros 8 , Patrick Little 9 , Patricia Pozo-Rosich 10 11 , Uwe Reuter 12 , Elena Ruiz de la Torre 9 , Margarita Sanchez Del Rio 13 , Alexandra J Sinclair 14 15 , Paolo Martelletti 16 17 , Zaza Katsarava 18 19 20 21 , Burden and Attitude to Resistant and Refractory (BARR) Study Group
Background: New treatments are currently offering new opportunities and challenges in clinical management and research in the migraine field. There is the need of homogenous criteria to identify candidates for treatment escalation as well as of reliable criteria to identify refractoriness to treatment. To overcome those issues, the European Headache Federation (EHF) issued a Consensus document to propose criteria to approach difficult-to-treat migraine patients in a standardized way. The Consensus proposed well-defined criteria for resistant migraine (i.e., patients who do not respond to some treatment but who have residual therapeutic opportunities) and refractory migraine (i.e., patients who still have debilitating migraine despite maximal treatment efforts). The aim of this study was to better understand the perceived impact of resistant and refractory migraine and the attitude of physicians involved in migraine care toward those conditions.
Methods: We conducted a web-questionnaire-based cross-sectional international study involving physicians with interest in headache care.
Results: There were 277 questionnaires available for analysis. A relevant proportion of participants reported that patients with resistant and refractory migraine were frequently seen in their clinical practice (49.5% for resistant and 28.9% for refractory migraine); percentages were higher when considering only those working in specialized headache centers (75% and 46% respectively). However, many physicians reported low or moderate confidence in managing resistant (8.1% and 43.3%, respectively) and refractory (20.7% and 48.4%, respectively) migraine patients; confidence in treating resistant and refractory migraine patients was different according to the level of care and to the number of patients visited per week. Patients with resistant and refractory migraine were infrequently referred to more specialized centers (12% and 19%, respectively); also in this case, figures were different according to the level of care.
Conclusions: This report highlights the clinical relevance of difficult-to-treat migraine and the presence of unmet needs in this field. There is the need of more evidence regarding the management of those patients and clear guidance referring to the organization of care and available opportunities.
CITA DEL ARTÍCULO J Headache Pain. 2021 May 18;22(1):39. doi: 10.1186/s10194-021-01252-4