Biochemical biomarkers for multiple sclerosis
Julia Maroto-García 1 , Ana Martínez-Escribano 2 , Virginia Delgado-Gil 3 , Minerva Mañez 3 , Carmen Mugueta 4 , Nerea Varo 4 , Ángela García de la Torre 5 , Maximiliano Ruiz-Galdón 6
Introduction: Multiple sclerosis (MS) is the most frequent demyelinating disease of the central nervous system. Although there is currently there is no definite cure for MS, new therapies have recently been developed based on a continuous search for new biomarkers. Development MS diagnosis relies on the integration of clinical, imaging and laboratory findings as there is still no singlepathognomonicclinical feature or diagnostic laboratory biomarker. The most commonly laboratory test used is the presence of immunoglobulin G oligoclonal bands (OCB) in cerebrospinal fluid of MS patients. This test is now included in 2017 McDonald criteria as a biomarker of dissemination in time. Nevertheless, there are other biomarkers currently in use such as kappa free light chain, which has shown higher sensitivity and specificity for MS diagnosis than OCB. In addition, other potential laboratory tests involved in neuronal damage, demyelination and/or inflammation could be used for detecting MS.
Conclusions: CSF and serum biomarkers have been reviewed for their use in MS diagnosis and prognosis to stablish an accurate and prompt MS diagnosis, crucial to implement an adequate treatment and to optimize clinical outcomes over time.
CITA DEL ARTÍCULO Clin Chim Acta. 2023 Jul 5;117471. doi: 10.1016/j.cca.2023.117471