Adoptive T-cell therapy with CD45RA-deplected donor in the treatment of cytomegalovirus disease in immunocompromised non-transplant patients

RESUMEN

Cytomegalovirus (CMV) infections can induce severe complications in immunosuppressed patients. Currently, ganciclovir represents the preferred treatment option; however, in patients with resistance or toxicity related to ganciclovir, the therapeutic options are limited.Cellular immunity plays an important role in the control of viral infections.

Adoptive T cell therapy can contribute to recovering immunological function in immunosuppressed patients. Selective T cell depletion targeting CD45RA enhances early T cell recovery and can represent a salvage therapy.

In this study, an immunocompromised non-transplanted patient with CMV disease and toxicity to conventional therapy was successfully treated by adoptive transfer of CD45RA-depleted T cells.

CITA DEL ARTÍCULO  Antivir Ther. 2019;24(4):313-319. doi: 10.3851/IMP3307