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Publicaciones científicas

Adipokines in the treatment of diabetes mellitus and obesity

01-feb-2009 | Revista: Expert Opinion on Pharmacotherapy

Victoria Catalán (1,3), Javier Gómez-Ambrosi (1,3), Amaia Rodríguez (1,3), Javier Salvador (2,3) & Gema Frühbeck (1,2,3)
(1) Clínica Universitaria de Navarra, Metabolic Research Laboratory, University of Navarra, Pamplona, Spain
(2) Department of Endocrinology, Clínica Universitaria de Navarra, Pamplona, Spain
(3) CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Spain


Background
The physiology of adipose tissue plays a main role in the pathogenesis of type 2 diabetes mellitus. The secretion of adipocyte-derived hormones, in either an autocrine or a paracrine manner, has been proposed as a relevant mechanism in this process. In this sense, the administration and regulation of hormones derived from adipose tissue arises as an attractive option for treating metabolic disorders.

Objective
To review the current understanding of the implication of adipokines in the development of obesity and insulin resistance, as well as their potential use as therapeutic agents.

Methodology
Review of scientific literature.

Conclusions
This review describes the role of adipokines in generating insulin resistance and the chronic low-grade inflammatory profile accompanying visceral obesity.

CITA DEL ARTÍCULO  Expert Opin Pharmacother. 2009 Feb;10(2):239-54