Publicaciones científicas

A typical antipsychotics normalize low-gamma evoked oscillations in patients with schizophrenia

26-nov-2016 | Revista: Psychiatry Research

Alegre M (1), Molero P (2), Valencia M (3), Mayner G (2), Ortuño F (2), Artieda J (4).
(1) Clinical Neurophysiology Section, Clínica Universidad de Navarra, Pamplona, Spain; Neurophysiology Laboratory, CIMA (Centre for Applied Medical Research) Universidad de Navarra, Pamplona, Spain.
(2) Department of Psychiatry, Clínica Universidad de Navarra, Pamplona, Spain.
(3) Neurophysiology Laboratory, CIMA (Centre for Applied Medical Research) Universidad de Navarra, Pamplona, Spain.
(4) Clinical Neurophysiology Section, Clínica Universidad de Navarra, Pamplona, Spain; Neurophysiology Laboratory, CIMA (Centre for Applied Medical Research) Universidad de Navarra, Pamplona, Spain 


RESUMEN

The symptoms of schizophrenia might be mediated by a cortical network disconnection which may disrupt the cortical oscillatory activity. Steady-state responses are an easy and consistent way to explore cortical oscillatory activity.

A chirp-modulated tone (increasing the frequency of the modulation in a linear manner) allows a fast measure of the steady-state response to different modulation rates. With this approach, we studied the auditory steady-state responses in two groups of patients with schizophrenia (drug-naive and treated with atypical antipsychotic drugs), in order to assess the differences in their responses with respect to healthy subjects, and study any potential effect of medication.

Drug-naive patients had reduced amplitude and inter-trial phase coherence of the response in the 30-50Hz range, and reduced amplitude of the response in the 90-100Hz range, when compared to controls. In the treated patients group, the response in the 30-50Hz range was normalized to values similar to the control group, but the reduction in amplitude in the 90-100Hz range remained as in the drug-naive group.

These results suggest that gamma activity impairment in schizophrenia is a complex phenomenon that affects a wide band of frequencies and may be influenced by antipsychotic treatment.

CITA DEL ARTÍCULO  Psychiatry Res. 2016 Nov 26;247:214-221. doi: 10.1016/j.psychres.2016.11.030