A Possible Mechanism for Flecainide Induced Dizziness

Objective: Flecainide is an oral class IC antiarrhythmic drug whose most common extracardiac adverse reactions are "dizziness" and "visual disturbances." We describe a case of flecainide associated- bilateral vestibulopathy and a literature review of this drug's effect on the vestibular system.

Patient: Sixty-nine-year-old man with a 3-month history of unsteadiness and dizziness after an increase in the dose of flecainide.

Interventions: Otologic examination, video head-impulse test, vestibular evoked myogenic potentials, pure tone audiometry and high-resolution magnetic resonance imaging.

Results: Otologic examination, including the head-impulse test, and vestibular testing revealed bilateral vestibulopathy.

Conclusions: Dizziness is a common extracardiac adverse reaction of Flecainide. Based on the clinical case that we present and the literature review carried out, we hypothesized that a possible mechanism by which flecainide might cause dizziness and visual disturbances is bilateral vestibulopathy.

CITA DEL ARTÍCULO  Otol Neurotol. 2022 Jun 1;43(5):e597-e601.
doi: 10.1097/MAO.0000000000003508. Epub 2022 Feb 24.