Publicaciones científicas

Hypoglossal nerve stimulation long-term clinical outcomes: a systematic review and meta-analysis

Costantino A (1), Rinaldi V (1), Moffa A (2), Luccarelli V 1, Bressi F (3), Cassano M (4), Casale M (1), Baptista P (5).

(1) Unit of Otolaryngology, UOS ORL TI, Campus Bio-Medico University, Rome, Italy.
(2) Unit of Otolaryngology, University of Foggia, Foggia, Italy.
(3) Department of Physical and Rehabilitation Medicine, Campus Bio-Medico University, Rome, Italy.
(4) Unit of Otolaryngology, University of Foggia, Foggia, Italy.
(5) Unit of Otolaryngology, Clínica Universidad de Navarra, Pamplona, Spain.

Revista: Sleep Breath

Fecha: 15-ago-2019

Otorrinolaringología

OBJECTIVE:

To perform a systematic review and meta-analysis for studies evaluating hypoglossal nerve stimulation (HNS) clinical outcomes in the treatment of moderate to severe obstructive sleep apnea (OSA).

METHODS:

Two authors conducted a literature search to identify prospective studies in PubMed/MEDLINE, Google Scholar, and Cochrane Library databases. The last search was performed on November 17, 2018.

RESULTS:

A total of 350 patients (median age 54.3 (IQR 53-56.25) years, BMI 29.8 (IQR 28.8-31.6) kg/m2) from 12 studies were included. The procedure has obtained a surgical success rate of 72.4% (Inspire), 76.9% (ImThera), 55% (Apnex) at 12 months, and 75% (Inspire) at 60-month follow-up. At 12 months, the apnea-hypopnea index (AHI) mean differences was - 17.50 (Inspire; 95% CI: - 20.01 to - 14.98, P < 0.001), - 24.20 (ImThera; 95% CI: - 37.39 to 11.01, P < 0.001), and - 20.10 (Apnex; 95% CI: - 29.62 to - 10.58, P < 0.001). The AHI mean reduction after 5 years was - 18.00 (Inspire, - 22.38 to - 13.62, P < 0.001). The Epworth sleepiness scale (ESS) mean reduction was - 5.27 (Inspire), - 2.90 (ImThera), and - 4.20 (Apnex) at 12 months and - 4.40 (Inspire) at 60 months, respectively. Only 6% of patients reported serious device-related adverse events after 1- and 5-year follow-up.

CONCLUSION:

HNS has obtained a high surgical success rate with reasonable long-term complication rate related to the device implanted. The procedure represents an effective and safe surgical treatment for moderate-severe OSA in selected adult patients who had difficulty accepting or adhering to CPAP treatment.

CITA DEL ARTÍCULO  Sleep Breath. 2019 Aug 15. doi: 10.1007/s11325-019-01923-2

tal vezLE INTERESE

¿QUÉ TECNOLOGÍA UTILIZAMOS?

La Clínica es el hospital privado con mayor dotación tecnológica de España, todo en un único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

NUESTROS
PROFESIONALES

Los profesionales de la Clínica realizan una labor continuada de investigación y formación, siempre en beneficio del paciente.

Imagen profesionales de la Clínica Universidad de Navarra

POR QUÉ VENIR
A LA CLÍNICA

Conozca por qué somos diferentes a otros centros sanitarios. Calidad, rapidez, comodidad y resultados.

Imagen del edificio de la Clínica Universidad de Navarra