Publicaciones científicas

The Metabolic and Hepatic Impact of Two Personalized Dietary Strategies in Subjects with Obesity and Nonalcoholic Fatty Liver Disease: The Fatty Liver in Obesity (FLiO) Randomized Controlled Trial

22-oct-2019 | Revista: Nutrients

Marin-Alejandre BA (1), Abete I (2,3), Cantero I (4), Monreal JI (5,6), Elorz M (7,8), Herrero JI (9,10,11), Benito-Boillos A (12,13), Quiroga J (4,15,16), Martinez-Echeverria A (17,18), Uriz-Otano JI (19,20), Huarte-Muniesa MP (21,22), Tur JA (23,24), Martinez JA (25,26,27), Zulet MA (28,29,30).

(1) Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.
(2) Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.
(3) Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
(4) Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.
(5) Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
(6) Clinical Chemistry Department, Clinica Universidad de Navarra 31008, Pamplona, Spain.
(7) Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
(8) Department of Radiology, Clinica Universidad de Navarra, 31008 Pamplona, Spain.
(9) Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
(10) Liver Unit, Clinica Universidad de Navarra 31008, Pamplona, Spain.
(11) Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain.
(12) Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
(13) Department of Radiology, Clinica Universidad de Navarra, 31008 Pamplona, Spain.
(14) Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
(15) Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), 28029 Madrid, Spain.
(16) Department of Internal Medicine, Clinica Universidad de Navarra, 31008 Pamplona, Spain.
(17) Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
(18) Department of Gastroenterology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain.
(19) Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
(20) Department of Gastroenterology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain.
(21) Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
(22) Department of Gastroenterology, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain.
(23) Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
(24) Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands, 07122 Palma, Spain.
(25) Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.
(26) Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
(27) Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.
(28) Department of Nutrition, Food Sciences and Physiology and Centre for Nutrition Research, Faculty of Pharmacy and Nutrition, University of Navarra, 31008 Pamplona, Spain.
(29) Biomedical Research Centre Network in Physiopathology of Obesity and Nutrition (CIBERobn), Instituto de Salud Carlos III, 28029 Madrid, Spain.
(30) Navarra Institute for Health Research (IdiSNA), 31008 Pamplona, Spain.


The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. NAFLD management is mainly focused on weight loss, but the optimal characteristics of the diet demand further investigation.

This study aims to evaluate the effects of two personalized energy-restricted diets on the liver status in overweight or obese subjects with NAFLD after a 6 months follow-up.

Ninety-eight individuals from the Fatty Liver in Obesity (FLiO) study were randomized into two groups and followed different energy-restricted diets. Subjects were evaluated at baseline and after 6 months. Diet, anthropometry, body composition, and biochemical parameters were evaluated. Liver assessment included ultrasonography, Magnetic Resonance Imaging, elastography, and determination of transaminases. Both dietary groups significantly improved their metabolic and hepatic markers after the intervention, with no significant differences between them.

Multivariate regression models evidenced a relationship between weight loss, adherence to the Mediterranean Diet (MedDiet), and a decrease in liver fat content, predicting up to 40.9% of its variability after 6 months. Moreover, the antioxidant capacity of the diet was inversely associated with liver fat content. Participants in the group with a higher adherence to the MedDiet showed a greater reduction in body weight, total fat mass, and hepatic fat.

These results support the benefit of energy-restricted diets, high adherence to the MedDiet, and high antioxidant capacity of the diet for the management of NAFLD in individuals with overweight or obesity.

CITA DEL ARTÍCULO  Nutrients. 2019 Oct 22;11(10). pii: E2543. doi: 10.3390/nu11102543

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