Publicaciones científicas

Subthalamic role on the generation of spikes in temporal epilepsy

01-feb-2009 | Revista: Epilepsy Research

Elena Urrestarazu (a), Jorge Iriarte (a), Manuel Alegre (a), Jorge Guridi (a,b), María Cruz Rodríguez-Oroz (a,b), José Obeso (a,b), César Viteri (a) and Julio Artieda (a)

(a) Department of Neurology and Neurosurgery, Clínica Universitaria and Medical School, and Neurosciences Division, CIMA University of Navarra, Pamplona, Spain(b) Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Spain


We report the electrophysiological findings in an unusual patient with temporal lobe epilepsy and subthalamic stimulators implanted to treat Parkinson's disease. Temporal and frontotemporal spikes were observed in the EEG.

Temporal spikes spread to the STN in a 40% of cases, involving simultaneously all contacts. Frontotemporal spikes showed more frequent STN propagation (70%), shorter delays, and progressive spread from ventral to dorsal contacts than temporal spikes.

These results suggest that a direct fronto-subthalamic pathway might account for the fast propagation of the frontotemporal spikes to the ventral STN.

CITA DEL ARTÍCULO  Epilepsy Res. 2009 Feb;83(2-3):257-60