Publicaciones científicas

Revisiting the Ghrelin Changes Following Bariatric and Metabolic Surgery

22-abr-2020 | Revista: Obesity Surgery

Tuero C (1,2), Valenti V (3,4,5,6), Rotellar F (3,4,5,6), Landecho MF (3,7), Cienfuegos JA (3,4,5,6), Frühbeck G (8,9,10,11).

(1) Obesity Area, Clínica Universidad de Navarra, Avenida Pio XII 36, 31008, Pamplona, Navarra, Spain.
(2) Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain.
(3) Obesity Area, Clínica Universidad de Navarra, Avenida Pio XII 36, 31008, Pamplona, Navarra, Spain.
(4) Department of Surgery, Clínica Universidad de Navarra, Pamplona, Spain.
(5) CIBEROBN, Instituto de Salud Carlos III, Pamplona, Navarra, Spain.
(6) Obesity and Adipobiology Group, IdiSNA, Pamplona, Spain.
(7) Department of Internal Medicine, General Health Check-up unit, Clínica Universidad de Navarra, Pamplona, Spain.
(8) Obesity Area, Clínica Universidad de Navarra, Avenida Pio XII 36, 31008, Pamplona, Navarra, Spain.
(9) CIBEROBN, Instituto de Salud Carlos III, Pamplona, Navarra, Spain.
(10) Obesity and Adipobiology Group, IdiSNA, Pamplona, Spain.
(11) Department of Endocrinology and Nutrition, Clínica Universidad de Navarra, Pamplona, Spain.


Since the description of ghrelin in 1999, several studies have dug into the effects of this hormone and its relationship with bariatric surgery. While some aspects are still unresolved, a clear connection between ghrelin and the changes after metabolic surgery have been established. Besides weight loss, a significant amelioration in obesity-related comorbidities following surgery has also been reported.

These changes in patients occur in the early postoperative period, before the weight loss appears, so that amelioration may be mainly due to hormonal changes.

The purpose of this review is to go through the current body of knowledge of ghrelin's physiology, as well as to update and clarify the changes that take place in ghrelin concentrations following bariatric/metabolic surgery together with their potential consolidation to outcomes.

CITA DEL ARTÍCULO  Obes Surg. 2020 Apr 22. doi: 10.1007/s11695-020-04601-5.