Publicaciones científicas

RELINF: prospective epidemiological registry of lymphoid neoplasms in Spain. A project from the GELTAMO group

20-feb-2020 | Revista: Annals of Hematology

Bastos-Oreiro M 1,2, Muntañola A 3, Panizo C 4, Gonzalez-Barca E 5, de Villambrosia SG 6, Córdoba R 7, López JLB 8, González-Sierra P 9, Terol MJ 10, Gutierrez A 11, Grande C 12, Ramirez MJ 13, Iserte L 14, Perez E 15, Navarro B 16, Gomez P 17, Salar A 18, Luzardo H 19, López A 20, Del Campo R 21, García-Belmonte D 22, Vida MJ 23, Infante M 24, Queizan-Hernandez JA 25, Novelli S 26, Moreno M 27, Penarrubia M 28, Gómez J 29, Domingo A 30, Donato E 31, Viguria MC 32, López F 33, Rodriguez MJ 34, Pardal E 35, Noriega V 36, Andreu R 37, Peñalver J 38, Martín A 39, Caballero D 39, López-Guillermo A 40.

1 Haematology Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
2 Health Research Institute, Gregorio Marañon, Madrid, Spain. 
3 Haematology Department, Hospital Universitario Mutua Tarrasa, Tarrasa, Cataluña, Spain.
4 Haematology Department, Clínica Universitaria de Navarra, Navarra, Spain.
5 Haematology Department, ICO Duran y Reinalds, Bellvitlle, Cataluña, Spain.
6 Haematology Department, Hospital of Valdesillas, Santander, Cantabria, Spain.
7 Haematology Department, Fundación Jimenez Díaz, Madrid, Madrid, Spain.
8 Haematology Department, University of Santiago Hospital Clinic, Santiago de Compostela, Galicia, Spain.
9 Haematology Department, Hospital Virgen de las Nieves, Granada, Andalucía, Spain.
10 Haematology Department, Valencia Hospital Clinic, Valencia, Spain.
11 Haematology Department, Hospital Son Espases, Palma de Mallorca, Spain.
12 Haematology Department, Hospital 12 de Octubre, Madrid, Spain.
13 Haematology Department, Jerez de la Frontera Hospital, Andalucía, Spain.
14 Haematology Department, Hospital Arnau de Vilanova, Lleida, Cataluña, Spain.
15 Haematology department, Hospital Morales Meseguer, Murcia, Murcia, Spain.
16 Haematology Department, University Hospital Puerta de Hierro, Mahadahonda, Madrid, Spain.
17 Haematology Department, La Paz University Hospital, Madrid, Spain.
18 Haematology Department, Hospital del Mar, Barcelona, Cataluña, Spain.
19 Hospital Negrin, Las Palmas de Gran Canaria, Canary Islands, Spain.
20 Haematology Department, Hospital Vall d' Hebron, Barcelona, Cataluña, Spain.
21 Haematology Department, Hospital Son Llátzer, Palma de Mallorca, Spain.
22 Haematology Department, Hospital de la Zarzuela, Madrid, Spain.
23 Haematology Department, Hospital of León, León, Castilla y León, Spain.
24 Haematology Department, Hospital Infanta Leonor, Madrid, Spain.
25 Haematology Department, Hospital de Segovia, Segovia, Castilla y León, Spain.
26 Haematology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Cataluña, Spain.
27 Haematology Department, Hospital Germans Trials y Pujol, Badalona, Cataluña, Spain.
28 Haematology Department, Hospital Clinic of Valladolid, Castilla y León, Spain.
29 Haematology Department, Hospital Virgen de la Arrixaca, El Palmar, Murcia, Spain.
30 Haematology Department, Hospital de Granollers, Barcelona, Cataluña, Spain.
31 Haematology Department, Hospital Dr. Peset, Valencia, Spain.
32 Haematology Department, Hospital of Navarra, Navarra, Spain.
33 Hospital Arnau de Vilanova, Valencia, Spain.
34 Haematology Department, Hospital Universitario de Canarias SCT, Tenerife, Canary Islands, Spain.
35 Haematology Department, Hospital Virgen del Puerto, Cáceres, Extremadura, Spain.
36 Haematology Department, University Hospital A Coruña, A Coruña, Galicia, Spain.
37 Haematology Department, Hospital La Fe, Valencia, Spain.
38 Haematology Department, Hospital of Alcorcón, Alcorcón, Madrid, Spain.
39 Haematology Department, Hospital Clinic of Salamanca, Salamanca, Castilla y León, Spain.
40 Haematology Department, Hospital Clinic of Barcelona, Barcelona, Cataluña, Spain.


Lymphomas are a large, heterogeneous group of neoplasms with well-defined characteristics, and this heterogeneity highlights the importance of epidemiological data.

Knowledge of local epidemiology is essential to optimise resources, design clinical trials, and identify minority entities. Given there are few published epidemiological data on lymphoma in Spain, the Spanish Lymphoma and Autologous Bone Marrow Transplant Group created the RELINF project.

The aim of this project is to determine the frequencies and distribution of lymphoid neoplasms in Spain and to analyse survival. We developed an online platform for the prospective collection of data on newly diagnosed cases of lymphoma in Spain between January 2014 and July 2018; 11,400 patients were registered. Diffuse large B cell lymphoma (DLBCL) and follicular lymphoma (FL) were the most frequent lymphomas in our series.

Marginal B cell lymphoma frequency was higher than that reported in other studies, representing more than 11% of mature B cell lymphomas. Peripheral T cell lymphoma not otherwise specified (PTCL-NOS) was the most common subtype of T cell lymphoma, and NK/T cell lymphomas were more frequent than expected (5.4% of total). Hodgkin's lymphoma accounted for 12% of lymphoproliferative syndromes.

Overall survival was greater than 90% at 2 years for indolent B cell lymphomas, and approximately 60% for DLBCL, somewhat lower than that previously reported. Survival was poor for PTCL-NOS and angioimmunoblastic T cell lymphoma, as expected; however, it was somewhat better than that in other studies for anaplastic large cell anaplastic lymphoma kinase lymphomas. This is the first prospective registry to report the frequencies, distribution, and survival of lymphomas in Spain. The frequencies and survival data we report here are globally consistent with that reported in other Western countries.

These updated frequencies and survival statistics are necessary for developing appropriate management strategies for neoplasias in the Spanish population.

CITA DEL ARTÍCULO  Ann Hematol. 2020 Feb 20. doi: 10.1007/s00277-020-03918-6

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