Publicaciones científicas

Pulmonary arterial enlargement predicts long-term survival in COPD patients

de-Torres JP (1), Ezponda A (2), Alcaide AB (1), Campo A (1), Berto J (1), Gonzalez J (1), Zulueta JJ (1), Casanova C (3), Rodriguez-Delgado LE (4), Celli BR (5), Bastarrika G (2).

(1) Pulmonary Department, Clínica Universidad de Navarra, Pamplona, Spain.
(2) Radiology Department, Clínica Universidad de Navarra, Pamplona, Spain.
(3) Pulmonary Department, Tenerife, Spain.
(4) Radiology Department, Hospital Ntra Sra de Candelaria, Tenerife, Spain.
(5) Pulmonary Department, Brigham and Women Hospital, Boston, MA, United States of America.

Revista: PLoS One

Fecha: 25-abr-2018

Radiología Neumología

RATIONALE:
Pulmonary artery enlargement (PAE) is associated with exacerbations in Chronic Obstructive Pulmonary Disease (COPD) and with survival in moderate to severe patients.

The potential role of PAE in survival prediction has not been compared with other clinical and physiological prognostic markers.

METHODS:
In 188 patients with COPD, PA diameter was measured on a chest CT and the following clinical and physiological parameters registered: age, gender, smoking status, pack-years history, dyspnea, lung function, exercise capacity, Body Mass Index, BODE index and history of exacerbations in year prior to enrolment. Proportional Cox regression analysis determined the best predictor of all cause survival.

RESULTS:
During 83 months (±42), 43 patients died. Age, pack-years history, smoking status, BMI, FEV1%, six minute walking distance, Modified Medical Research Council dyspnea scale, BODE index, exacerbation rate prior to enrollment, PA diameter and PAE (diameter≥30mm) were associated with survival. In the multivariable analysis, age (HR: 1.08; 95%CI: 1.03-1.12, p<0.001) and PAE (HR: 2.78; 95%CI: 1.35-5.75, p = 0.006) were the most powerful parameters associated with all-cause mortality.

CONCLUSIONS:
In this prospective observational study of COPD patients with mild to moderate airflow limitation, PAE was the best predictor of long-term survival along with age.

CITA DEL ARTÍCULO  PLoS One. 2018 Apr 25;13(4):e0195640. doi: 10.1371/journal.pone.0195640

tal vezLE INTERESE

¿QUÉ TECNOLOGÍA UTILIZAMOS?

La Clínica es el hospital privado con mayor dotación tecnológica de España, todo en un único centro.

Imagen de un PET, tecnología de vanguardia en la Clínica Universidad de Navarra

NUESTROS
PROFESIONALES

Los profesionales de la Clínica realizan una labor continuada de investigación y formación, siempre en beneficio del paciente.

Imagen profesionales de la Clínica Universidad de Navarra

POR QUÉ VENIR
A LA CLÍNICA

Conozca por qué somos diferentes a otros centros sanitarios. Calidad, rapidez, comodidad y resultados.

Imagen del edificio de la Clínica Universidad de Navarra