Publicaciones científicas

Histopathological findings in fatal COVID-19 severe acute respiratory syndrome: preliminary experience from a series of 10 Spanish patients

24-ago-2020 | Revista: Thorax

Borja Recalde  1   2 , Laura García-Tobar  3 , Alan Argueta  3 , Laura Álvarez  3 , Carlos Eduardo De Andrea  3 , Mirian Fernández Alonso  4 , Ana Ezponda  5 , Francisco Carmona Torre  2   4 , Carlota Jordán Iborra  2   6 , Jorge Augusto Quiroga  2   6   7 , Jose Luis Del Pozo  2   4 , Javier J Zulueta  1   2 , Gema Echarri  8 , Manuel F Landecho #  9   6 , Maria Dolores Lozano #  3   10   11

(1) Service of Pulmonary Medicine, Clinica Universitaria, Pamplona, Spain.
(2) Covid19 Department, Clinica UNiversidad de Navarra, Pamplona, Navarra, Spain.
(3) Pathology, University of Navarra, Pamplona, Navarra, Spain.
(4) Microbiology and infectious diseases, Clinica Universidad de Navarra, Pamplona, Spain.
(5) Radiology, Clinica Universitaria de Navarra, Pamplona, Spain.
(6) Internal Medicine, Clinica Universidad de Navarra, Pamplona, Spain.
(7) CIBEREHD, CIBER, Pamplona, Spain.
(8) Intensive Care Unit, Clínica Universidad de Navarra, Pamplona, Navarra, Spain.
(9) Covid19 Department, Clinica UNiversidad de Navarra, Pamplona, Navarra, Spain mflandecho@unav.es.
(10) Centro de Investigación Biomédica en Red, Madrid, Comunidad de Madrid, Spain.
(11) Instituto de Investigación Sanitaria de Navarra, Pamplona, Navarra, Spain.
#Contributed equally.
 


 Abstract

In December 2019, an outbreak of severe acute respiratory syndrome associated to SARS-CoV2 was reported in Wuhan, China. To date, little is known on histopathological findings in patients infected with the new SARS-CoV2.

Lung histopathology shows features of acute and organising diffuse alveolar damage. Subtle cellular inflammatory infiltrate has been found in line with the cytokine storm theory. Medium-size vessel thrombi were frequent, but capillary thrombi were not present.

Despite the elevation of biochemical markers of cardiac injury, little histopathological damage could be confirmed. Viral RNA from paraffin sections was detected at least in one organ in 90% patients.

CITA DEL ARTÍCULO  Thorax. 2020 Aug 24;thoraxjnl-2020-215577. doi: 10.1136/thoraxjnl-2020-215577Dr. Francisco Carmona de la Torre