Publicaciones científicas

Functional Relationship between Leptin and Nitric Oxide in Metabolism

06-sep-2019 | Revista: Nutrients

Becerril S (1,2,3), Rodríguez A (4,5,6), Catalán V (7,8,9), Ramírez B (10,11,12), Unamuno X (13,14,15), Portincasa P (16), Gómez-Ambrosi J (17,18,19), Frühbeck G (20,21,22,23).

(1) Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
(2) CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain.
(3) Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.
(4) Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
(5) CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain.
(6) Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.
(7) Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
(8) CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain.
(9) Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.
(10) Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
(11) CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain.
(12) Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.
(13) Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
(14) CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain.
(15) Medical Engineering Laboratory, University of Navarra, 31008 Pamplona, Spain.
(16) Clinica Medica "A. Murri", Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Policlinico Hospital, 70124 Bari, Italy.
(17) Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
(18) CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain.
(19) Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.
(20) Metabolic Research Laboratory, Clínica Universidad de Navarra, 31008 Pamplona, Spain.
(21) CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 31008 Pamplona, Spain.
(22) Obesity and Adipobiology Group, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain.
(23) Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, 31008 Pamplona, Spain.


Leptin, the product of the ob gene, was originally described as a satiety factor, playing a crucial role in the control of body weight.

Nevertheless, the wide distribution of leptin receptors in peripheral tissues supports that leptin exerts pleiotropic biological effects, consisting of the modulation of numerous processes including thermogenesis, reproduction, angiogenesis, hematopoiesis, osteogenesis, neuroendocrine, and immune functions as well as arterial pressure control.

Nitric oxide (NO) is a free radical synthesized from L-arginine by the action of the NO synthase (NOS) enzyme. Three NOS isoforms have been identified: the neuronal NOS (nNOS) and endothelial NOS (eNOS) constitutive isoforms, and the inducible NOS (iNOS). NO mediates multiple biological effects in a variety of physiological systems such as energy balance, blood pressure, reproduction, immune response, or reproduction.

Leptin and NO on their own participate in multiple common physiological processes, with a functional relationship between both factors having been identified. The present review describes the functional relationship between leptin and NO in different physiological processes.

CITA DEL ARTÍCULO  Nutrients. 2019 Sep 6;11(9). pii: E2129. doi: 10.3390/nu11092129

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