Publicaciones científicas

FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in human adipocytes

15-oct-2021 | Revista: Cellular & Molecular Immunology

Gema Frühbeck  1   2   3   4 , Victoria Catalán  1   2   3 , Víctor Valentí  2   3   5 , Rafael Moncada  2   3   6 , Javier Gómez-Ambrosi  1   2   3 , Sara Becerril  1   2   3 , Camilo Silva  2   3   4 , Piero Portincasa  7 , Javier Escalada  2   3   4 , Amaia Rodríguez  8   9   10


A sedentary lifestyle and obesity are important risk factors for severe COVID-19 complications and death [1, 2]. Excessive adipose tissue (AT) might contribute to more extensive viral spread with increased shedding, immune activation, and cytokine amplification [3].

Several factors secreted by contracting muscle, termed myokines, mediate the beneficial effects of exercise in a wide range of diseases, including obesity [4].

Thus, we conducted a study to explore the potential role of myokines of the fibronectin type III domain-containing family, FNDC4 and FNDC5, in mechanisms underlying the increased susceptibility to COVID-19 complications in obesity.

CITA DEL ARTÍCULO  Cell Mol Immunol. 2021 Oct;18(10):2457-2459.  doi: 10.1038/s41423-021-00762-0

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