Publicaciones científicas

COVID-19 prevalence and mortality in people with epilepsy: A nation-wide multicenter study

01-dic-2021 | Revista: Epilepsy & Behavior

Alvaro Sanchez-Larsen  1 , Estefanía Conde-Blanco  2 , Alejandro Viloria-Alebesque  3 , Cristina Sánchez-Vizcaíno Buendía  4 , Tatiana Espinosa Oltra  4 , Amanda Alvarez-Noval  5 , Angel Aledo-Serrano  6 , Raquel Martin-Garcia  7 , María E Ramos-Araque  8 , Dulce Campos  9 , Gonzalo Valle-Peñacoba  9 , Alicia Sierra-Gómez  10 , Pablo De Ceballos-Cerrajería  11 , Marta Agundez-Sarasola  11 , Mariam Khawaja  12 , Kevin G Hampel  13 , Maria Serra-Martínez  14 , Clara Arbós-Barber  14 , Asier Gómez-Ibáñez  15 , Rafael Villino-Boquete  16 , Pablo Cabezudo-García  17 , Ignacio Rodríguez-Lavado  17 , Alessandro Principe  18 , David Sopelana-Garay  19


Background: To assess the prevalence, severity, and mortality of COVID-19 in people with epilepsy (PWE) and evaluate seizure control in PWE during and after COVID-19.

Methods: Retrospective, observational, multicenter study conducted in 14 hospitals. Medical records of randomly selected PWE followed at neurology outpatient clinics were reviewed.

Proportion of PWE with a positive test for SARS-CoV-2 during 2020 was calculated. Risk factors associated with COVID-19 and its morbimortality were evaluated.

Results: 2751 PWE were included, mean age 48.8 years (18-99), 72.4% had focal epilepsy, and 35% were drug-refractory. COVID-19 prevalence in PWE was 5.53%, while in the Spanish population was 4.26%. Proportion of admissions to hospital, ICU, and deaths in PWE were 17.1%, 2%, and 4.61% of COVID-19 cases, while in Spanish population were 10.81%, 0.95%, and 2.57%, respectively.

A severe form of COVID-19 occurred in 11.8%; dyslipidemia, institutionalization at long-term care facilities, intellectual disability, and older age were associated risk factors. Older age, hypertension, dyslipidemia, cardiac disease, and institutionalization were associated with mortality from COVID-19. Seizure control was stable in 90.1% of PWE during acute COVID-19, while 8.6% reported an increase in seizure frequency. During post-COVID-19 follow-up, 4.6% reported seizure control worsening.

Conclusions: COVID-19 was moderately prevalent in PWE. One out of 5 patients required medical attention and 4.6% died due to COVID-19. Older age, dyslipidemia, institutionalization, and intellectual disability were significant risk factors associated with severe COVID-19. Seizure control remained stable during COVID-19 and throughout long-term follow-up in most PWE who contracted the infection.

CITA DEL ARTÍCULO  Epilepsy Behav. 2021 Dec;125:108379. doi: 10.1016/j.yebeh.2021.108379. Epub 2021 Oct 8. 

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