Publicaciones científicas

Consensus guidelines and recommendations for infection prevention in multiple myeloma: a report from the International Myeloma Working Group

01-feb-2022 | Revista: The Lancet. Haematology

Noopur S Raje  1 , Elias Anaissie  2 , Shaji K Kumar  3 , Sagar Lonial  4 , Thomas Martin  5 , Morie A Gertz  3 , Amrita Krishnan  6 , Parameswaran Hari  7 , Heinz Ludwig  8 , Elizabeth O'Donnell  9 , Andrew Yee  9 , Jonathan L Kaufman  4 , Adam D Cohen  10 , Laurent Garderet  11 , Ashutosh F Wechalekar  12 , Evangelos Terpos  13 , Navin Khatry  14 , Ruben Niesvizky  15 , Qing Yi  16 , Douglas E Joshua  17 , Tapan Saikia  18 , Nelson Leung  3 , Monika Engelhardt  19 , Mohamad Mothy  20 , Andrew Branagan  9 , Ajai Chari  21 , Anthony J Reiman  22 , Brea Lipe  23 , Joshua Richter  21 , S Vincent Rajkumar  3 , Jesús San Miguel  24 , Kenneth C Anderson  25 , Edward A Stadtmauer  10 , Rao H Prabhala  25 , Phillip L McCarthy  26 , Nikhil C Munshi  25


Abstract

Infection remains the leading cause of morbidity and mortality in patients with multiple myeloma because of the cumulative effect of disease, treatment, and host-related factors.

Given that infectious risk is cumulative through the course of the disease, preventing infections is paramount. Optimal preventive strategies include vaccination against common pathogens, antimicrobial prophylaxis, infection control measures, and immunoglobulin replacement in a small subset of patients; however, there are no universally accepted guidelines for infection prevention.

This Review provides a consensus statement from a panel of 36 experts with global representation, which was convened by The International Myeloma Society to review existing literature and current guidelines, address issues associated with the risk of infection and prevention of infectious complications in multiple myeloma in the context of emerging therapies, and offer recommendations for preventing these complications.

CITA DEL ARTÍCULO Lancet Haematol. 2022 Feb;9(2):e143-e161. doi: 10.1016/S2352-3026(21)00283-0